Quarterback

1. Drew Brees - Marques Colston is officially back (finally), and Brees, who was pretty stellar even without him, is going to unleash the 6'5" beast against everyone's favorite target-practice defense for the past decade or so, the Kansas City Chiefs.
2. Kurt Warner - He's playing like an MVP, he's got three of the best receivers in football at his disposal, and he's matched up the Seahawks, who give up the second-most passing yards per game. What's not to love?
3. Jay Cutler - Atlanta has been pretty bad against the pass this season (11th-most yards per game), and Cutler has huge-game potential every time he steps on the field.
4. Peyton Manning - The Colts have built up a head of steam and are ready to unleash their revitalized passing game on the Texans.
5. Donovan McNabb - The Giants miraculously didn't sack McNabb once last week, and he was able to throw for three touchdowns against the best defense in the NFC. That doesn't bode well for Bengals fans this week. Assuming any of them show up. I wouldn't blame them for staying home.

Running Back

1. Frank Gore - Gore's neck injury doesn't sound like a big deal, so expect the 49ers to do what everyone else does to the Rams, who have given up the most rushing touchdowns in the NFL - run the ball down their throats.
2. Brian Westbrook - Expect the old Westbrook to show up in Cincinnati. The Giants contained him effectively last week, but they do that to pretty much everyone, so it's nothing to worry about.
3. Adrian Peterson - Tampa's a tough matchup, but he's on a serious roll so it probably won't matter.
4. Michael Turner - The matchup with the Broncos (27th against the run) is sweet; the Burner shouldn't disappoint.
5. Marshawn Lynch - Disregard this as a Bills fanboy pick if you must, but I've made peace with the fact that the 4-0 start to the season was a mirage. The frustration is boiling over in Buffalo, and with the lowly Browns and their #26 rush defense in town, it's high time for some Beast Mode.

Wide Receiver

1. Steve Smith - Aside from last week, he's been on fire, and he's up against the Lions (known by opponents as the Detroit "Hooray We Get To Play The" Lions). Last week's near-goose-egg was an aberration caused by the extreme imbalance in the Oakland defense - it makes no sense to pass on their 13th-ranked secondary, so everyone just runs it down the throat of their 29th-ranked rush defense.
2. Larry Fitzgerald - Boldin has been outperforming him, fantasy-wise, for the past two weeks, but I don't think there's any particular reason. Unless...
3. Anquan Boldin - Overheard outside Boldin's hospital room, 9/30/08: "Gentlemen, we can rebuild him. We have the technology. We have the capability to build the world's first bionic man. Anquan Boldin will be that man. Better than he was before. Better, stronger, faster."
4. Brandon Marshall - He's been dropping passes and making mistakes lately, but his talent and the matchup are too good for him to land outside the top five.
5. Reggie Wayne - He hasn't done anything to blow his owners' socks off so far this season, but this game marks the beginning of what should be a good stretch for him, with easy matchups just about every week for the remainder of the season. The ankle injury is a concern, but it sounds like he'll play.
   Edit: Somehow, I completely forgot about Colston here. He's a better start than Wayne. Against the Chiefs, he's easily a top-5 start this week.